€ 8.00 · 5 (636) · En stock
(1) Background: To explore the impact of the degree of inflammation on voriconazole exposure in critically ill patients affected by COVID-associated pulmonary aspergillosis (CAPA); (2) Methods: Critically ill patients receiving TDM-guided voriconazole for the management of proven or probable CAPA between January 2021 and December 2022 were included. The concentration/dose ratio (C/D) was used as a surrogate marker of voriconazole total clearance. A receiving operating characteristic (ROC) curve analysis was performed by using C-reactive protein (CRP) or procalcitonin (PCT) values as the test variable and voriconazole C/D ratio > 0.375 (equivalent to a trough concentration [Cmin] value of 3 mg/L normalized to the maintenance dose of 8 mg/kg/day) as the state variable. Area under the curve (AUC) and 95% confidence interval (CI) were calculated; (3) Results: Overall, 50 patients were included. The median average voriconazole Cmin was 2.47 (1.75–3.33) mg/L. The median (IQR) voriconazole concentration/dose ratio (C/D) was 0.29 (0.14–0.46). A CRP value > 11.46 mg/dL was associated with the achievement of voriconazole Cmin > 3 mg/L, with an AUC of 0.667 (95% CI 0.593–0.735; p < 0.001). A PCT value > 0.3 ng/mL was associated with the attainment of voriconazole Cmin > 3 mg/L (AUC 0.651; 95% CI 0.572–0.725; p = 0.0015). (4) Conclusions: Our findings suggest that in critically ill patients with CAPA, CRP and PCT values above the identified thresholds may cause the downregulation of voriconazole metabolism and favor voriconazole overexposure, leading to potentially toxic concentrations.
How to search full-text research articles for free
Macrolide Resistance in MORDOR I — A Cluster-Randomized Trial in Niger
Concentrations of various antibiotics in serum and fluids accumulated in diffusion chambers implanted in various sites in rabbits. - Abstract - Europe PMC
Popular Children's Antibiotic Liquid Amoxicillin Still In Shortage—Here Are Alternatives And What To Know
Antibiotic resistance, Definition, Mechanisms, Examples, & Facts
A great start: no growth hormones, antibiotics or gestation crate use. – Salute The Pig
Antibiotic Essentials 201
The meat industry's antibiotic drug problem, explained - Vox
Antibiotics, Free Full-Text, staphylococcus
Antibiotic resistance genes from livestock waste: occurrence, dissemination, and treatment
14,344 Antibiotic Resistance Images, Stock Photos, 3D objects, & Vectors
IJERPH, Free Full-Text
What Does 'Antibiotic Free' Mean When it Comes to Food? - Modern Farmer
BioActive Group - Research