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Saccharomyces boulardii, commonly referred to as S. boulardii, is a tropical species of yeast that was isolated from the lychee and mangosteen fruit in 1923 by French scientist Henri Boulard. Boulard first isolated the yeast after he observed natives of Southeast Asia chewing on the skin of lychee and mangosteen in an attempt to control the symptoms of cholera. In healthy patients, S.
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